A Multi-omic Approach for the Study of Heart Regeneration Using Zebrafish as a Model Organism Leanne Nye,1,2 Lee A. Gethings, 2 Shuk Han Cheng, 3 Yun Wah Lam, Fatemah Babei, Alfred W. H Chan, 3 Chi Chi Liu, 3 Yimin Liang, Robert S. Plumb, 1,2 and Ian D. Wilson 1 Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. 37 Full PDFs related to this paper. Fast external development and transparency during embryogenesis allow for visual screening at the macroscopical and microscopical level, including visualization of organogenesis. Although the main focus of zebrafish research has The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family of the order Cypriniformes.Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a "tropical fish" although both tropical and subtropical).. Figure 1. In conclusion, the zebrafish respond to EDC at environmentally realistic concentrations. Corpus ID: 5705819. Zebrafish (Danio rerio) are small tropical fish (2.5-4 cm long) found natively in south Asia.First used in the 1960s in biological research, Zebrafish have proven to be excellent model organisms for developmental and disease studies. Zebrafish as a new model organism for Parkinson ’ s disease @inproceedings{Willemsen2008ZebrafishAA, title={Zebrafish as a new model organism for Parkinson ’ s disease}, author={R. Willemsen and Wiebren Hasselaar and H. C. Linde and V. Bonifati}, year={2008} } Crossref We therefore selected this species as an ideal organism for the generation of a simplified, genetically tractable model using fluorescent neutrophils to track the inflammatory response. screening of … Zebrafish is a good model ?? In its larval stages it is transparent and as it matures to an adult it develops stripes … Although a substantial amount of research demonstrates the potential of zebrafish as a model of liver toxicity, there are a number of challenges. In this Primer, we provide a broad overview of the available tools for regeneration research in the zebrafish, and focus on the challenges and opportunities presented by this model organism. This provides insight into the genetic control of developmental processes in humans because their genomes are similar. Accepted: 01/09/2014 Abstract The zebrafish ( Danio rerio) has become a widely used vertebrate model organism for drug discovery because of its hi gh fecundity, transparent embryos and larvae, morphological and p hysiological similarity to mammals, allowing in vivo analysis of embryogenesis and organogenesis combined with ease of use and low cost. Its use in modelling human disease has numerous advantages over other animals as zebrafish have a fully sequenced genome, high fecundity, short generation interval (3–4 months), rapid embryonic development, external fertilisation and translucent embryos. Zebrafish is a small teleost (bony) fish used in many areas of pharmacology and toxicology. In this framework, the zebrafish is a versatile animal model organism for many research fields because of its many advantages, including rapid embriyonic development, easy maintenance and transparency of its embryos. Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. The zebrafish has developed into an important model organism for biomedical research over the last decades. As the zebrafish model organism database, ZFIN facilitates research by providing a central database and a uniform interface to integrate and view the large amount of diverse data ( 1). Zebrafish are being increasingly used as a model organism to study vertebrate hematopoiesis. 1 There are so many species-specific differences in many aspects of growth and nutrition 4 Zebrafish metabolism is very different from most cultured species because it lives in constant water temperatures 2 Nutritional requirements for each developmental stage are not completely established in zebrafish Since their discovery for use in research in Prague in the 1980’s, this fish has been established in many laboratories worldwide. The zebrafish genome shows up to 80% similarity with human disease-associated genes. This paper. This animal model has advantages for the discovery of anti-inflammatory drugs, such as the potential for real-time assessment of cell migration mechanisms. The zebrafish is a commonly used model organism in the biological sciences, similar to the mouse or rat. In general, several model systems Zebrafish … Zebrafish as a Cancer Model Harma Feitsma and Edwin Cuppen Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, the Netherlands Abstract The zebrafish has developed into an important model organism for biomedical research over the last decades. Among the most rapidly … Zebrafish are increasingly seen as a promising model organism in which to investigate neurodevelopment because their young, or larvae, are transparent, making it possible to image the whole brain in real time. There is a significant growth in amount numbers of scientific literature pertaining to research discoveries in reproductive sciences in zebrafish. After its introduction for scientific investigation in the 1950s, the cypriniform zebrafish, Danio rerio, has become a valuable model for the study of regenerative processes and mechanisms.Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regenerate lost tissue such as limbs, heart muscle, brain, retina, and spinal cord. the research community working with this model organism, also in the context of regeneration. Key facts. Zebrafish can grow to 4-5 cm and are easily handled in aquatic systems. The zebrafish offers a number of features, such as its rapid development, tractable genetics, suitability for in vivo imaging and chemical screening, that make it an attractive model to cancer researchers. ZFIN data derive from expert manual curation of scientific literature, collaboration with major resource centers and submissions from individual investigators. The zebrafish (Danio rerio) is a freshwater teleost of the family Cyprinidae that is established as a model organism in many research fields.Here, we define the characteristics that a fish species should have to serve as a model for finfish aquaculture research and argue that the zebrafish … atlas of zebrafish development Nov 23, 2020 Posted By Barbara Cartland Publishing TEXT ID 430efbad Online PDF Ebook Epub Library Atlas Of Zebrafish Development INTRODUCTION : #1 Atlas Of Zebrafish Best Book Atlas Of Zebrafish Development Uploaded By Barbara Cartland, the atlas of zebrafish development aims to provide a reference at the gross anatomical level for We demonstrated that C. albicans can colonize and invade zebrafish at multiple anatomical sites and kill the fish in a dose-dependent manner. Review Article Zebrafish as a Model for the Study of ... zebrafish have become an important model organism, especially in biomedical research. Although no animal can perfectly model a human disease, I believe these little striped swimmers have great potential for advancing medical research in the future. Classically, the zebrafish model organism has been used to elucidate the genetic and cellular mechanisms related to development since the embryo forms and grows externally following fertilization. The use of zebrafish as a model organism was pioneered to overcome some of the difficulties that plague other vertebrate model organisms such as in utero development, low offspring number, lack of genetic tractability, and high maintenance costs. Zebrafish are often exposed to a drug by dissolving the drug in the water, which enables easy and fast drug administration. Zebrafish is a widely used model organism in many different fields of research. The fish also develop rapidly, and researchers can simply add drugs to … The zebrafish is extensively used as a vertebrate model for human diseases [1,2,3,4,5,6] and other conditions such as aging, development and genetics [7,8,9,10,11,12,13,14,15,16].The small fish presents many advantages as a model; therefore, it cannot be overlooked and has not been since Dr. George Streisinger convinced the world in the 1980s of the wonders of the zebrafish [17,18,19]. The use of zebrafish (Danio rerio) as a model organism began in the 1960s.The zebrafish is a tropical fish native to southeast Asia. The zebrafish has emerged in recent years as a pre-eminent vertebrate model organism for studies aimed at understanding gene function and human disease. Today, it has emerged as a favored vertebrate organism for the research in science of reproduction. A short summary of this paper. High fecundity and short generation times facilitate genetic analyses. The timing of the adoption of zebrafish as an emerging model organism could not be better, as mouse studies often fail to translate to humans. In this work, the zebrafish model organism was developed to obtain a minivertebrate host system for a Candida albicans infection study. Zebrafish, a freshwater tropical fish, is a premiere model organism to study vertebrate development. Download Full PDF Package. Moreover, thanks to a well-conserved physiology, the pharmacological behavior and metabolism of several drugs have been screened in zebrafish with effects similar to humans. Farmanur Rahman Khan, Saleh Sulaiman Alhewairini, Zebrafish (Danio rerio) as a Model Organism, Current Trends in Cancer Management [Working Title], 10.5772/intechopen.73816, (2018). In the past, it was a major vertebrate model especially in the developmental and genetic research (Hill et al., 2005). ease processes (e.g., vertebrates such as zebrafish and mice). Advantages of using Zebrafish as a Model Organism. Although the main focus of zebrafish research has traditionally been on developmental biology, keeping and observing zebrafish in the lab led to the identification of diseases similar to humans, such as cancer, which subsequently became a subject for study. Challenges in using zebrafish as a new model for DILI. The zebrafish, Danio rerio (a tropical and small freshwater fish), is an early vertebrate model organism. Application of this zebrafish partial life-cycle test on a chemically complex pulp mill effluent revealed both estrogenic and androgenic effects. The utilization of zebrafish in biomedical research is very common in the research world nowadays. Tools for studying regeneration in zebrafish The results support that zebrafish is a suitable model … The zebrafish is about 2.5 cm to 4 cm long. Zebrafish has become a popular model in pharmacological studies for e.g. This genetically tractable model has many appealing features, such as the ease of manipulation of transparent embryos and the capacity to carry out large-scale genetic and chemical screens ( … The zebrafish (Danio rerio) is one of the best animal models to understand biological mechanisms and develop new methods for treating some human diseases. ZFIN is dedicated to supporting the research community in this ongoing effort. Zebrafish as a relevant model for human dise ase and cancer therapy. This Primer will provide a synopsis of the different cancer models generated by the zebrafish … MODEL ORGANISMS: ADVANTAGES AND LIMITATIONS OF THE VARIOUS SYSTEMS In this section, we consider the strengths and limitations of several well-studied model organisms with regard to the analysis of human genetic disorders (see Table 3–1). 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